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Allergic mechanism of docetaxel and its treatment Health Articles | June 27, 2012
Docetaxel is insoluble in water. But it is soluble in a mixed solvent of polyoxyethylene castor oil and ethanol. Polyoxyethylene castor oil can release histamine in the degradation.
It may cause allergic reactions. Allergic reactions occurred in the first or the second medication for most of patients. Almost all of them occur within 30 minutes after administration. Timely anti-allergy treatment can quickly relieve symptoms and will not cause serious consequences. So although docetaxel cost is reasonable and welcomes Ecco Casual Shoes Australia , patients should be cautious when using it in curing diseases.
The severities of allergic reactions caused by docetaxel are different. The light manifested as flushing, itching, urticaria, drug fever Cheap Ecco Sandals Australia , a severe allergic reaction mainly hypotension, bronchospasm, asthma, and anaphylactic shock. Serious allergic reactions to the rate of 25% to 30% Ecco Sandals Australia , pre-treatment routine to the glucocorticoid, diphenhydramine and H2 blockers by the incidence dropped to 1.5% ~ 3.0%. But the main symptoms of an allergic reaction to laryngospasm is not mentioned in the instructions of the class of drugs, clinicians should be alert to allergic reactions in the use of taxane chemotherapy. They should not just depend on drug manual guidance.
The laryngospasm is dangerous. Quickly diagnosis and differential diagnosis are particularly important. The following adverse reactions to docetaxel due to laryngospasm instant attack shortly after the start of the chemotherapy inspiratory dyspnea characterized with chemotherapy-induced phase identification; often before the onset of palpitations, shortness of breath Cheap ECCO Dress Australia , the main complaint, with blood pressure, migraine low heart rate and other symptoms; ECG manifested as sinus tachycardia, arrhythmia with ECG for identification; acute laryngeal edema: allergy caused by acute upper airway obstruction caused by difficulty in breathing ECCO Dress Australia , but the incidence of slow. In addition, the differential diagnosis should also be noted that patients with or without a history of other respiratory and circulatory system.
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